Biological Mass Spectrometry Lab

The Biological Mass Spectrometry Laboratory develops and applies advanced methods to improve the understanding of diseases, pathways, targets, and drug effects.

The laboratory provides a full proteomics and metabolomics infrastructure for the identification and quantification of proteins, small molecules and lipids.

The laboratory is centered around two high-resolution mass spectrometer coupled to liquid chromatography, one bidimensional gas chromatography mass spectrometry and one triple-quadrupole mass spectrometer. The laboratory is well equipped and has experience on the analysis of molecules from different matrices, i.e. from biomedical, environmental, food and many other fields. The laboratory offers also the data analysis, pathway analysis and omics data integration.

The Mission:

• Study the biochemistry using mass spectrometry techniques

• Apply advanced proteomics and metabolomics to improve the knowledge of diseases, pathways, targets and drug effects

• Develop and optimize experimental and computational techniques to support basic and clinical research needs

• Accelerate discovery in science by giving researchers access to cutting edge technologies in proteomics and metabolomics

• Collaborate with UPO scientists, external researchers and industries

News

Open position: 1 year post-doc position available on metabolomics and lipidomics with LC-MS. (contact: marcello.manfredi@uniupo.it)

2020

Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2, Elettra Barberis, Sara Timo, Elia Amede, Virginia V. Vanella, Chiara Puricelli, Giuseppe Cappellano, Davide Raineri, Micol G. Cittone, Eleonora Rizzi, Anita R. Pedrinelli, Veronica Vassia, Francesco G. Casciaro, Simona Priora, Ilaria Nerici, Alessandra Galbiati, Eyal Hayden, Marco Falasca, Rosanna Vaschetto, Pier Paolo Sainaghi, Umberto Dianzani, Roberta Rolla, Annalisa Chiocchetti, Gianluca Baldanzi, Emilio Marengo, Marcello Manfredi*, International Journal of Molecular Science, 2020.

FAM46C and FNDC3A are multiple myeloma tumor suppressors that act in concert to impair clearing of protein aggregates and autophagy, Nicola Manfrini, Marilena Mancino, Annarita Miluzio, Stefania Oliveto, Matteo Balestra, Piera Calamita, Roberta Alfieri, Riccardo Rossi, Marco Sassoè-Pognetto, Chiara Salio, Alessandro Cuomo, Tiziana Bonaldi, Marcello Manfredi, Emilio Marengo, Elia Ranzato, Simona Martinotti, Davide Cittaro, Giovanni Tonon, and Stefano Biffo, Cancer Research 2020.

Determination by ICP-MS and multivariate data analysis of elemental urine excretion profile during the EDTA chelation therapy: A case study, Elisa Robotti, Fabio Quasso, Marcello Manfredi, Fabio Gosetti, Eleonora Mazzucco, Ciro Isidoro, Emilio Marengo, Journal of Trace Elements in Medicine and Biology, 2020.

Exploring the wound healing, anti-inflammatory, anti-pathogenic and proteomic effects of lactic acid bacteria on keratinocytes, Jessica Brandi, Samuele Cheri, Marcello Manfredi, Claudia Di Carlo, Virginia Vita Vanella, Federica Federici, Eleonora Bombiero, Alda Bazaj, Eleonora Rizzi, Laura Manna, Giuseppe Cornaglia, Umberto Marini, Maria Teresa Valenti, Emilio Marengo, Daniela Cecconi, Scientific Reports volume 10, Article number: 11572 (2020).

Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice, Giulia Dematteis, Gabrielė Vydmantaitė, Federico Alessandro Ruffinatti, Malak Chahin, Serena Farruggio, Elettra Barberis, Eleonora Ferrari, Emilio Marengo, Carla Distasi, Ramunė Morkūnienė, Armando A. Genazzani, Mariagrazia Grilli, Elena Grossini, Marco Corazzari, Marcello Manfredi, Dmitry Lim, Aistė Jekabsone, Laura Tapella, Cell Death & Disease volume 11, Article number: 645 (2020).

The mutant P53-driven secretome has oncogenic functions in pancreatic ductal adenocarcinoma cells, Giovanna Butera, Jessica Brandi, Chiara Cavallini, Aldo Scarpa, Rita T. Lawlor, Maria Teresa Scupoli, Emílio Marengo, Daniela Cecconi, Marcello Manfredi* and Massimo Donadelli*, Biomolecules 2020, 10(6), 884.

Organoid-Transplant Model Systems to Study the Effects of Obesity on the Pancreatic Carcinogenesis in vivo, Francesca Lupo, Geny Piro, Lorena Torroni, Pietro Delfino, Rosalinda Trovato, Borislav Rusev, Alessandra Fiore, Dea Filippini, Francesco De Sanctis, Marcello Manfredi, Emilio Marengo, Rita Teresa Lawlor, Maurizio Martini, Giampaolo Tortora, Stefano Ugel, Vincenzo Corbo, Davide Melisi, Carmine Carbone, Frontiers in cell and developmental biology, vol 8 pag 308, 2020.

Proteomic and Ultrastructural Analysis of Cellulite—New Findings on an Old Topic, Giamaica Conti, Nicola Zingaretti, Domenico Amuso, Elena Dai Prè, Jessica Brandi, Daniela Cecconi, Marcello Manfredi, Emilio Marengo, Federico Boschi, Michele Riccio, Roberto Amore, Eugenio Luigi Iorio, Alice Busato, Francesco De Francesco, Valentina Riccio, Pier Camillo Parodi, Luca Vaienti, Andrea Sbarbati, Int. J. Mol. Sci. 2020, 21(6), 2077.

Enterococcus faecium NCIMB10415 responds to norepinephrine by altering protein profiles and phenotypic characters, R. Scardaci, F. Varese, M. Manfredi, E. Marengo, R. Mazzoli, E. Pessione, Journal of Proteomics, Volume 231, 16 January 2021, 104003.

Clostridium cellulovorans metabolism of cellulose as studied by comparative proteomic approach, Giulia Usai, Simona Cirrincione, Angela Re, Marcello Manfredi, Andrea Pagnani, Enrica Pessione, Roberto Mazzoli, Journal of Proteomics, Volume 216, 30 March 2020, 103667.

Extracellular Vesicles in Human Preterm Colostrum Inhibit Infection by Human Cytomegalovirus In Vitro, Donalisio, M.; Cirrincione, S.; Rittà, M.; Lamberti, C.; Civra, A.; Francese, R.; Tonetto, P.; Sottemano, S.; Manfredi, M.; Lorenzato, A.; Moro, G.E.; Giribaldi, M.; Cavallarin, L.; Giuffrida, M.G.; Bertino, E.; Coscia, A.; Lembo, D. Microorganisms 2020, 8, 1087.

Identification of a caleosin associated to hazelnut (Corylus avellana L.) oil bodies, Cristina Lamberti, Stefano Nebbia, Raffaella Balestrini, Emilio Marengo, Marcello Manfredi, Vera Pavese, Simona Cirrincione, Maria Gabriella Giuffrida, Laura Cavallarin, Alberto Acquadro, Simona Abbà, Plant Biology, 16684991, 10.1111/plb.13096.

Effect of hot air and infrared roasting on hazelnut allergenicity, Cristina Lamberti, Stefano Nebbia, Sara Antoniazzi, Simona Cirrincione, Emilio Marengo, Marcello Manfredi, Denis Smorgon, Giovanna Monti, Antonella Faccio ,Maria Gabriella Giuffrida, Raffaella Balestrini, Laura Cavallarin, Food Chemisty, 2020.

Biostimulants applied to maize seeds modulate the enzymatic activity and metaproteome of the rhizosphere, Monica Mattarozzia, Jessica Di Zinno, Barbara Montanini, Marcello Manfredi, Emilio Marengo, Flavio Fornasier, Andrea Ferrarini, Maria Careri, Giovanna Visioli, Applied Soil Ecology, Volume 148, April 2020, 103480.

2019

The Anti-Apoptotic Effect of ASC-Exosomes in an In Vitro ALS Model and Their Proteomic Analysis, Roberta Bonafede, Jessica Brandi, Marcello Manfredi, Ilaria Scambi, Lorenzo Schiaffino, Flavia Merigo, Ermanna Turano, Bruno Bonetti, Emilio Marengo, Daniela Cecconi, Raffaella Mariotti, Cells, 2019.

Identification of haptoglobin as a readout of rhGH therapy in GH deficiency, Marilisa De Feudis, Gillian Elisabeth Walker, Giulia Genoni, Marcello Manfredi, Emanuela Agosti, Mara Giordano, Marina Caputo, Luisa Di Trapani, Emilio Marengo, Gianluca Aimaretti, Nicoletta Filigheddu, Simonetta Bellone, Gianni Bona, Flavia Prodam, The Journal of Clinical Endocrinology & Metabolism, jc.2019-00562, https://doi.org/10.1210/jc.2019-00562.

The Cockroach Allergen‐like protein is involved in primary respiratory and food allergy to yellow mealworm (Tenebrio molitor), Nebbia S, Lamberti C, Giorgis V, Giuffrida MG, Manfredi M, Marengo E, Pessione E, Schiavone A, Boita M, Brussino L, Cavallarin L, Rolla G., Clin Exp Allergy. 2019 Jul 15. doi: 10.1111/cea.13461.

Investigation of the protein profile of silkworm (Bombyx mori) pupae reared on a well-calibrated artificial diet compared to mulberry leaf diet, Cristina Lamberti, Francesco Gai​, Simona Cirrincione, Marzia Giribaldi, Micol Purrotti, Marcello Manfredi, Emilio Marengo, Benedetto Sicuro, Alessio Saviane, Silvia Cappellozza, Maria Gabriella Giuffrida, Laura Cavallarin, PeerJ, 2019.

Runx2 stimulates neoangiogenesis through the Runt domain in melanoma, Daniela Cecconi, Jessica Brandi, Marcello Manfredi, Michela Serena, Luca Dalle Carbonare, Michela Deiana, Samuele Cheri, Francesca Parolini, Alberto Gandini, Giulia Marchetto, Giulio Innamorati, Francesco Avanzi, Franco Antoniazzi, Emilio Marengo, Natascia Tiso, Monica Mottes, Donato Zipeto & Maria Teresa Valenti, Scientific Reports, volume 9, Article number: 8052 (2019).

Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton, A. Adamo, J. Brandi, S. Caligola, P. Delfino, R. Bazzoni, R. Carusone, D. Cecconi, R. Giugno, M. Manfredi, E. Robotti, E. Marengo, G. Bassi, P. T. Kamga, G. Dal Collo, A. Gatti, A. Mercuri, M. Arigoni, M. Olivero, R. A. Calogero, M. Krampera, Frontiers in Immunology Volume: 10 (2019) ISSN: 1664-3224

New Insights into the Runt Domain of RUNX2 in Melanoma Cell Proliferation and Migration, M. Deiana, L. Dalle Carbonare, M. Serena, S. Cheri, F. Parolini, A. Gandini, G. Marchetto, G. Innamorati, M. Manfredi, E. Marengo, J. Brandi, D. Cecconi, A. Mori, M. Mina, F. Antoniazzi, M. Mottes, N. Tiso, G. Malerba, D. Zipeto, M. Valenti, Cells, Vol 7, 11, p220, 11/2018.

Mining cancer biology through bioinformatic analysis of proteomic data, Marcello Manfredi, Jessica Brandi, Claudia Di Carlo, Virginia Vita Vanella, Elettra Barberis, Emilio Marengo, Mauro Patrone, Daniela Cecconi, Expert Review of Proteomics, Volume 16, 2019 - Issue 9.

Plasma Proteome Profiles of Stable CAD Patients Stratified According to Total Apo C-III Levels, M. Manfredi, C. Chiariello, E. Conte, A. Castagna E. Robotti, F. Gosetti, M. Patrone, N. Martinelli, A. Bassi, D. Cecconi, E. Marengo, O. Olivieri, Proteomics Clin Appl. 2019 Jul 10:e1800023. doi: 10.1002/prca.201800023.

Integrated serum proteins and fatty acids analysis for putative biomarker discovery in inflammatory bowel disease, M. Manfredi, E. Conte, E. Barberis, A. Buzzi, E. Robotti, V. Caneparo, D. Cecconi, J. Brandi, E. Vanni, M. Finocchiaro, M. Astegiano, M. Gariglio, E. Marengo, M. De Andrea. Journal of Proteomics, 2 Nov 2018, https://doi.org/10.1016/j.jprot.2018.10.017.

New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053, Laurent R. Chiarelli, Elena G. Salina, Giorgia Mori, Tatyana Azhikina, Olga Riabova, Alexander Lepioshkin, Artem Grigorov, Martin Forbak, Jan Madacki, Beatrice Silvia Orena, Marcello Manfredi, Fabio Gosetti, Arianna Buzzi, Giulia Degiacomi, José Camilla Sammartino, Emilio Marengo, Jana Korduláková, Giovanna Riccardi, Katarína Mikušová, Vadim Makarov, Maria Rosalia Pasca, ACS Infect. Dis. 2019.

Investigating the Proteomic Profile of HT-29 Colon Cancer Cells After Lactobacillus kefiri SGL 13 Exposure Using the SWATH Method, Jessica Brandi, Claudia Di Carlo, Marcello Manfredi, Federica Federici, Alda Bazaj, Eleonora Rizzi, Giuseppe Cornaglia, Laura Manna, Emilio Marengo, Daniela Cecconi, J. Am. Soc. Mass Spectrom. (2019). https://doi.org/10.1007/s13361-019-02268-6.

Analysis of Toll-Like Receptors in Human Milk: Detection of Membrane-Bound and Soluble Forms, Chiara Cattaneo, Alice Caramaschi, Elena Uga, Michela Braghin, Gianluca Cosi, Chiara Peila, Maria C. Strozzi, Miriam Sabatini, Diego Gazzolo, Marcello Manfredi, Maria Cavaletto, Volume 2019 |Article ID 4078671 | 12 pages | https://doi.org/10.1155/2019/4078671.

Effect of Cyclic Stretch on Vascular Endothelial Cells and Abdominal Aortic Aneurysm (AAA): Role in the Inflammatory Response, M. Ramella, G. Bertozzi, L. Fusaro, M. Talmon, M. Manfredi, M. Calvo Catoria, F. Casella, C. M. Porta, R. Boldorini, L. G. Fresu, E. Marengo, F. Boccafoschi, Int. J. Mol. Sci. 2019, 20(2), 287; https://doi.org/10.3390/ijms20020287.

Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer’s disease mouse model, F. Rocchio, L. Tapella, M. Manfredi, M. Chisari, F. Ronco, F. A. Ruffinatti, E. Conte, P. L. Canonico, M. A. Sortino, M. Grilli, E. Marengo, A. A. Genazzani, D. Lim, Cell Death & Diseasevolume 10, Article number: 24 (2019).

A Proteomic Approach to the Safeguard of a Typical Agri-Food Product: Fiore Sardo PDO, Maria Mazza, Guglielmetti C, Brusadore S, Simona Sciuto, Giovanna Esposito, Maria Caramelli, Simone Peletto, Pier Luigi Acutis, Emilio Marengo, Marcello Manfredi, Luigi Cucca and Michele Boi, Advances in Diary Research 2019

Metaproteomic characterization of theVitis vinifera rhizosphere, E Bona, N Massa, G Novello, L Boatti, P Cesaro, V Todeschini, V Magnelli, M Manfredi, E Marengo, F Mignone, G Berta, G Lingua, E Gamalero, FEMS Microbiology Ecology, Volume 95, Issue 1, January 2019, fiy204.

Leonardo's Donna Nuda unveiled, Elettra Barberis, Marcello Manfredi, Emilio Marengo, Gleb Zilberstein, Svetlana Zilberstein, Alexander Kossolapov, Pier Giorgio Righetti, Journal of Proteomics, Volume 207, 15 September 2019, 103450.

Monitoring of water quality inflow and outflow of a farm in Italian Padana plain for rice cultivation: a case study of two years, Fabio Gosetti, Elisa Robotti, Bianca Bolfi, Eleonora Mazzucco, Fabio Quasso, Marcello Manfredi, Simone Silvestri, Arianna Facchi, Emilio Marengo, Environ Sci Pollut Res (2019) 26: 21274. https://doi.org/10.1007/s11356-019-05155-5.

Structural and functional differentiation of the light‐harvesting protein Lhcb4 during land plant diversification, P. Albanese, M. Manfredi, E. Marengo, G. Saracco, C. Pagliano, Physiologia Plantarum, 11 March 2019 https://doi.org/10.1111/ppl.12964.

2018

Study of endocrine disrupting compound release from different medical devices through an on-line SPE UHPLC-MS/MS method, F. Gosetti, B. Bolfi, E. Robotti, M. Manfredi, M. Binotti, F. Ferrero, G. Bona, E. Marengo, Analytica Chimica Acta, Volume 1042, 26 December 2018, Pages 141-154.

Sialylated isoforms of apolipoprotein C-III and plasma lipids in subjects with coronary artery disease, Oliviero Olivieri, Carmela Chiariello, Nicola Martinelli, Annalisa Castagna, Giulia Speziali, Domenico Girelli, Francesca Pizzolo, Antonella Bassia, Daniela Cecconi, Elisa Robotti, Marcello Manfredi, Eleonora Conte and Emilio Marengo, Clin Chem Lab Med 2018.

Relevance of inflammation and matrix remodeling in abdominal aortic aneurysm (AAA) and popliteal artery aneurysm (PAA) progression, Ramella, M., Bernardi, P., Fusaro, L., Manfredi, M., Casella, F., Porta, C.M., Nicolai, L., Galeazzi, E., Boldorini, R., Settembrini, A.M., Settembrini, P., Marengo, E., Cannas, M., Boccafoschi, F., American Journal of Translational Research, Volume 10, Issue 10, 2018, Article number AJTR0081199, Pages 3265-3275.

Can half-marathon affect overall health? The yin-yang of sport, Dalle L. Carbonare, M. Manfredi, G. Caviglia, E. Conte, E. Robotti, E. Marengo, S. Cheri, F. Zamboni, D. Gabbiani, M. Deiana, D. Cecconi, F. Schena, M. Mottes, M.T. Valenti, Journal of Proteomics, 170, pp. 80-87, 2018. 10.1016/j.jprot.2017.09.004.

Fetuin B links vitamin D deficiency and pediatric obesity: Direct negative regulation by vitamin D, Gillian E. Walker, Antonia Follenzi, Valentina Bruscaggin, Marcello Manfredi, Simonetta Bellone, Emilio Marengo, Luigi Maiuri, Flavia Prodam, Gianni Bona, Journal of Steroid Biochemistry and Molecular Biology Volume 182, September 2018, Pages 37-49, https://doi.org/10.1016/j.jsbmb.2018.04.009.

Proteomic approaches to decipher cancer cell secretome, J. Brandi, M. Manfredi, G. Speziali, F. Gosetti, E. Marengo, D. Cecconi, Seminars in Cell and Developmental Biology, 2017, doi.org/10.1016/j.semcdb.2017.06.030.

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK, L.R. Chiarelli, G. Mori, B.S. Orena, M. Esposito, T. Lane, A. Ribeiro, G. Degiacomi, J. Zemanová, S. Szádocka, S. Huszár, Z. Palčeková, M. Manfredi, F. Gosetti, J. Lelièvre, L. Ballell, E. Kazakova, V. Makarov, E. Marengo, K. Mikusova, S.T. Cole, G. Riccardi, S. Ekins, M.R. Pasca, Scientific Reports, volume 8, Article number: 3187 (2018), https://doi.org/10.1038/s41598-018-21614-4.

Trichostatin A alters cytoskeleton and energy metabolism of pancreatic adenocarcinoma cells: an in depth proteomic study, E. Dalla Pozza, M. Manfredi, J. Brandi, A. Buzzi, E. Conte, R. Pacchiana, D. Cecconi, E. Marengo, M. Donadelli, Journal of Cellular Biochemistry, 119(3), pp. 2696-27072017, https://doi.org/10.1002/jcb.26436.

IEF peptide fractionation method combined to shotgun proteomics enhances the exploration of rice milk proteome, M. Manfredi, J. Brandi, E. Conte, P. Pidutti, F. Gosetti, E. Robotti, E. Marengo, D. Cecconi, Analytical Biochemistry, 537, pp. 72-77, 2017, 10.1016/j.ab.2017.08.021.

Thylakoid proteome modulation in pea plants grown at different irradiances: quantitative proteomic profiling in a non-model organism aided by transcriptomic data integration, P. Albanese, M. Manfredi, A. Re, E. Marengo, G. Saracco, C. Pagliano, The Plant Journal, Volume96, Issue4, November 2018, Pages 786-800.

Response of the thylakoid proteome of Synechocystis sp. PCC 6803 to photohinibitory intensities of orange-red light, A. Cordara, M. Manfredi, P. Alphen, E. Marengo, R. Pirone, G. Saracco, F. Branco dos Santos, K. J. Hellingwerf, C. Pagliano, Plant Physiology and Biochemistry, Volume 132, November 2018, Pages 524-534.

Photodegradation of the pure and formulated alpha-cypermethrin insecticide gives different products, F. Gosetti, B. Bolfi, U. Chiuminatto, M. Manfredi, E. Robotti, E. Marengo, Environmental Chemistry Letters, June 2018, Volume 16, Issue 2, pp 581–590.

LC–MS/MS Approach for the Identification of Unknown Degradation Products of Dyes in Beverages, F. Gosetti, B. Bolfi, E. Mazzucco, M. Manfredi, E. Robotti, E. Marengo, Natural and Artificial Flavoring Agents and Food Dyes, Handbook of Food Bioengineering, 2018, Pages 229-260.

Metaproteomic characterization of theVitis vinifera rhizosphere, E. Bona, N. Massa, G. Novello, L. Boatti, P. Cesaro, V. Todeschini, V. Magnelli, M. Manfredi, E. Marengo, F. Mignone, G. Berta, G. Lingua, E. Gamalero, FEMS Microbiology Ecology, Volume 95, Issue 1, January 2019, fiy204.

Fast classification of hazelnut cultivars through portable infrared spectroscopy and chemometrics, M. Manfredi, E. Robotti, F. Quasso, E. Mazzucco, G. Calabrese, E. Marengo, Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 189, pp. 427-435, 2018.

Towards the Non-invasive Proteomic Analysis of Cultural Heritage Objects, E. Barberis, S. Baiocco, E. Conte, F. Gosetti, A. Rava, G. Zilberstein, P.G. Righetti, E. Marengo, M. Manfredi, Microchemical Journal, 2018.

Cellulomonas fimi secretomes: In vivo and in silico approaches for the lignocellulose bioconversion, S. Spertino, L. Boatti, S. Icardi, M. Manfredi, C. Cattaneo, E. Marengo, M. Cavaletto, J Biotechnol. 2018 Jan 31; 270:21-29.

Two-dimensional gel and shotgun proteomics approaches to distinguish fresh and frozen-thawed curled octopus (Eledone cirrhosa), C. Guglielmetti, M. Manfredi, S. Brusadore, S. Sciuto, G. Esposito, P. G. Ubaldi, L. Magnani, S. Gili, E. Marengo, P. L. Acutis, M. Mazza, Journal of Proteomics, Volume 186, 30 August 2018, Pages 1-7, https://doi.org/10.1016/j.jprot.2018.07.017

2017

Pea PSII-LHCII supercomplexes form pairs by making connections across the stromal gap, P. Albanese, R. Melero, B.D. Engel, A. Grinzato, P. Berto, M. Manfredi, A. Chiodoni, J. Vargas, C.Ó.S. Sorzano, E. Marengo, G. Saracco, G. Zanotti, J.-M. Carazo, C. Pagliano, Scientific Reports, 7(1),10067, 2017, https://doi.org/10.1038/s41598-017-10700-8.

A metaproteomic approach dissecting major bacterial functions in the rhizosphere of plants living in serpentine soil, M. Mattarozzi, M. Manfredi, B. Montanini, F. Gosetti, A.M. Sanangelantoni, E. Marengo, M. Careri, G. Visioli, Anal Bioanal Chem, 409:2327–2339, 2017, 10.1007/s00216-016-0175-8.

The antioxidant uncoupling protein 2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreas cancer cells to glycolysis inhibition, J. Brandi, D. Cecconi, M. Cordani, M. Torrens-Mas, R. Pacchiana, E. Dalla Pozza, G. Butera, M. Manfredi, E. Marengo, J. Oliver, P. Roca, I. Dando, M. Donadelli, Free Radical Biology and Medicine 101 (2016) 305–316, 10.1016/j.freeradbiomed.2016.10.499.

Cell autonomous and noncell-autonomous role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells, S. Cvijetic, V. Bortolotto, M. Manfredi, E. Ranzato, E. Marengo, P. L. Canonico, M. Grilli, Glia, 65(1), pp. 169-181, 2017, 10.1002/glia.23085.

Method for Noninvasive Analysis of Proteins and Small Molecules from Ancient Objects, M. Manfredi, E. Barberis, F. Gosetti, E. Conte, G. Gatti, C. Mattu, E. Robotti, G. Zilberstein, I. Koman, S. Zilberstein, E. Marengo, and P. G. Righetti, Anal. Chem. 2017, 89, 3310−3317.

Photodegradation of the pure and formulated alpha-cypermethrin insecticide gives different products, F. Gosetti, B. Bolfi, U. Chiuminatto, M. Manfredi, E. Robotti, E. Marengo, Environmental Chemistry Letters, pp 1–10, 2017.

Non-invasive characterization of colorants by portable diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy and chemometrics, M. Manfredi, E. Barberis, M. Aceto, E. Marengo, Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 181, pp. 171-179, 2017.

A hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the identification and determination of cationic starch derivatives in air samples, F. Gosetti, E. Mazzucco, A. Secco, E. Robotti, M. Manfredi, E. Marengo, Analytical Methods, 9(10), pp. 1634-1642, 2017.

Prediction and classification of the degradation state of plastic materials used in modern and contemporary art, M. Manfredi, E. Barberis, E. Marengo, Applied Physics A: Materials Science and Processing, 123(1), 35, 2017.

Optimization of the Extraction of the Volatile Fraction from Honey Samples by SPME-GC-MS, Experimental Design, and Multivariate Target Functions, E. Robotti, F. Campo, M. Riviell, E. Mazzucco, M. Manfredi, E. Sangiorgi, E. Marengo, Journal of Chemistry,6437857, 2017.